Detoxification

Detoxification is a process of neutralizing toxins in our system particularly in the lymph nodes and liver and then eliminating them through our lungs, colon, skin, and kidneys. This process is vital to our system as is nutrient intake, and it is a process that our system engages in as consistently as our heartbeat. Without these systems working properly, the toxins would then embed themselves in our tissues and trigger a host of degenerative diseases and inflammatory conditions which could include mental symptomatology such as anxiety and psychosis. When overloaded and if the body cannot neutralize and eliminate a toxin, it will sequester it away in fatty tissues including glandular, nerve, and brain tissue. In an effort to protect us from dangerous poisons; the body can accumulate mucous and fat to deposit these toxins in.

The scale of toxins we are currently exposed to put an unreasonable demand on our detoxification physiology. Industrial chemicals and the water treatment process pollutes the water we bathe in and often drink. Pesticides designed to poison insects are accumulating in our bodies, the concentration of mercury permeates the food chain along with other heavy metals, your household cleaners, solvents, the declination of our air quality, your hygiene products, and our environmental hormones all put an undue burden on our system, inevitably resulting in the breakdown of our natural body systems. Energy metabolism, neurotransmitter synthesis, addictive biochemistry, the disruption of normal hormonal production, interference of DNA and tissue repair, and other delicate biochemical systems are additionally adversely affected. The World Health Organization research has implicated environmental chemicals in 60-80% of all cancers today. We have seen this toxic load as correlatively and directly responsible for mental issues including psychosis, anxiety, hormonal disruption, addictive disorders, and underlying allergic and chemical sensitivities.

Our immune system serves the purpose of protecting us from infection. It does so by making a distinction between the self (the body) and the non-self (a foreign invader). When it detects an invader, such as a pathogen, – it will identify it closely. It will then send out the equivalent of a wanted poster to all the white blood cells, informing them of the invader. When the white blood cells come in contact with the pathogen, they set off an inflammatory process and begin the attack of the pathogen.

The immune system is being asked to distinguish self from non-self when it comes to toxin laden tissue. Often, the immune system mistakes this toxic tissue with “foreign invaders” and then proceeds to attack it. This is a likely mechanism for some cases of auto-immune issues such as Multiple Sclerosis, Lupus, Crohn’s disease, rheumatoid arthritis, Graves’ disease, Psoriatic Arthritis, and a host of others. The immune system attacks tissues that are toxic without realizing the “attack” is on itself.

Signs of toxicity ⁱ

• Frequent unexplained headaches
• Chronic respiratory problems, sinus problems or asthma
• Abnormal body odor, bad breath or coated tongue
• Environmental sensitivities, sensitivity to odors
• Food allergies, poor digestion, constipation, intestinal bloating and gas
• Unusually poor memory, chronic insomnia, depression, chronic fatigue
• Brittle hair and nails, psoriasis, adult acne, unexplained weight gain

As different toxins debilitate different systems, different symptoms may present.
We commonly see Mercury toxicity create insomnia and anxiety. Arsenic toxicity has been known to contribute to pain killer abuse due to its effects on endorphin synthesis, and Mercury-Lead or Mercury-Aluminum combinations have been demonstrated in psychosis as they bind to neuronal receptor sites generally reserved for neurotransmitters and require chelation to restore normative functionality.

Additional signs of Heavy Metal and Pollution Toxicity ⁱⁱ

• Sensitivity to perfumes and cleaning products
• Low tolerance to alcohol
• Sensitivity to medications
• Sensitivity to certain supplements
• Usually bad breath and body odor
• Slow reaction time for your age
• Infertility, Impotency
• Memory failure, psychotic behavior, unexplained seizures

Removal Process

To remove these toxins, specific techniques need to be employed. Heavy metal toxins and many environmental toxins are neurotoxic and lipophillic. Neurotoxic means that they have a high affinity for and are destructive to nerve tissue. Lipophillic means love of fat, and therefore aggregates in fatty tissue such as endocrine glands, brain tissue and adipose tissue. These toxins are termed fat-soluble. In order to remove them, they must be addressed in specific ways:

Chelation- Chelation means “claw like.” This, put simply, is a protein that has a higher affinity for the heavy metal than does the fatty tissue, and as a molecule, will grab the toxin like a claw. A protein chelate such a DMPS binds the heavy metal toxin, and allows it to be escorted out of the body via the elimination pathways. Chelate are specific for metals only, and other methods much be employed in conjunction to address organic toxins.

Conjugation- Conjugation means “with joining.” For non-metal organic toxins, this is the method elimination. In order for these fat soluble toxins to be eliminated via sweat, defecation and via urinary routes, they must be converted to a water soluble form. This is done by adding something to the toxin such as a sulfur group, methyl group, acetyl group and others. This adding is chemically termed conjoining. The specific elements in our detoxification process take full advantage of this process so that the toxins can be liberated from the fatty tissue, and safely eliminated.

Sauna Therapy- Once the toxins have been rendered water soluble, one of the best methods of elimination it through the skin. The skin is a tremendous organ of elimination, with the capacity to eliminate even beyond the capacity of the kidney in some respects by virtue of the sheer surface area. By using the skin as a detoxifying organ, we therefore unburden the kidneys and the liver. It should be noted that the sauna is most effective in this way due to the fact that the conjugative process has converted the toxins into a water soluble form. The sauna as a standalone process would only eliminate the water soluble toxins in the same way the urination would, and would not specifically impact nuerotoxic and fat soluble toxins.

ⁱ Adapted from Healthy Healing by Linda Page 12th ed. page 173

ⁱⁱ Adapted from Healthy Healing by Linda Page 12th ed. page 178

Chelative Sauna Program Training Guide

This is the complete Chelative Sauna Program

This program was designed for persons who have accumulated toxins and to specifically remove those toxins. It was taken into consideration that many persons participating in this program will be on medications for the symptoms they have been having. In most cases, the need for the medications will be reduced as a person progresses. These medication issues need to be addressed by a qualified medical professional. http://www.orthomolecular.org/ and http://www.alternativementalhealth.com/ are resources to find doctors who can help with medication issues.

A urine sample is gathered for 6 hours after the administration of the DMPS on day one. At the end of the process, which can be from 20-40 days (5 days per week), another urine test is collected for the 6 hours after the administration of the last oral DMPS.

The sauna is run for two hours, and short breaks are to be taken every 15 min to 30 min

At least 64 ounces of water need to be consumed, and preferably more

DMPS is administered once per week

On urine collection days (day one and final day), the urine will be collected for the 6 hours after the DMPS.

More sensitive persons may have do a modified schedule. Persons in active psychosis and anxiety that produces panic attacks, active Lyme or other pathogenic infection, and physical weakness would be some examples.

Each participant needs to be given a physical exam to determine if they have heart disease or highly elevated liver enzyme of any other physical limitation that would preclude their participation.

For active psychosis and anxiety, they modified programs would consider doing the following actions. The items of most concern are listed on the top, and the modification may include all, or some of the following actions working from the top down, and correlating that to the symptomatic severity. The idea is to not throw the person out of homeostasis, and if they are already out of balance, then

Decreasing overall time is sauna and exercise. Starting even at 15 minutes can be helpful to get progress so that more can be done. The supplementation, and even the entire chelative program could be run without sauna, however of course adding sauna then can use the skin as a detoxifying organ is very beneficial in clearing the toxins that are liberated from the chelative processes.

SamE- As Sam-E converts Norepinephrine to Epinephrine, the person may experience excitation depending on how overloaded with Norepinephrine they are.

DMPS- The DMPS can be withheld until the person stabilizes.

NAC- The NAC can be withheld until the person stabilizes.

EDTA- The EDTA can be withheld until the person stabilizes.

Vitamin C – May be reduced to 4 grams to start. There is a natural energizing effect to Vitamin C, and that effect may need to be taken into consideration for persons already excitable

The most basic formulation for even the most sensitive should include:

1 heaping tsp. of Chlorella in water
20 drops monotomic trace minerals
20-30 drops of Cilantro tincture
2 tbsp Matrix minerals

Biochemical Cycles demonstrating toxic effects on Metabolism

The following was captured from the Genova Nutreval test

CoFactors are substances that support a particular biochemical processes in the body.

Toxins are substances that inhibit certain biochemical processes in the body

Above is a small portion of a biochemical cycle involving carbohydrate metabolism. In order for Pyruvic Acid to convert into Acetyl CoA, you need the CoFactors listed in the green dot. As long as you have Magnesium (Mg), B1, B2, B3 and Lipoate, you should be able to manufacture Acetyl CoA. Toxins however invalidate this conversion process. The pinkish dot and the red line with the arrow though it represents things that inhibit the conversion from taking place. As, Hg, and Sb represent Arsenic, Mercury and Antimony. Presence of those toxins will likely inhibit this step regardless of ample CoFacors. The presence of toxins debilitates person’s ability to be able to make use of the nutrients they are consuming.

Acetyl CoA is a main factor in cellular respiration known as the Krebs Cycle, which produces energy for the cell. Acetyl CoA is also needed to convert Serotonin to Melatonin as seen below. Toxic inhibition of this process may result in insomnia, and the addition of dietary Melatonin would be ineffective as this conversion needs to take place within the brain, and Melatonin will not cross from the gut and blood to the brain.

The following was taken from the Genova Nutreval Test [Mercury inhibition added]

Mercury (Hg) is particularly toxic. It toxifies one of the main detoxification mediums, namely methlyation. In order to detoxify a fat soluble toxin, a CH3 group called a methyl group needs to be conjoined to the toxin. Mercury disables this process. Now, not only can the body not clear the Mercury, but becomes ineffective as clearing other toxins as well. So the Lead, Cadmium, Organic Phosphates and so on cannot be cleared. Mercury is also a factor is the above as Mercury will interfere with the adenylation of Methionine which creates endogenous Sam-E, another factor important in the conversion of Serotonin to Melatonin.

Sam-E also is needed in the conversion of Norepinephrine to Epinephrine as shown in the next cycle below. Build up of Norepinephrine results anxious states, and a relatively constant unwavering type of anxiety is a typical presentation of Mercury toxicity.

“I don’t feel comfortable using a substance designated by the Environmental Protection Agency to be a waste disposal hazard. I can’t throw it in the trash, bury it in the ground, or put it in a landfill, but they say it is OK to put it in people’s mouths. That doesn’t make sense.” – Richard. Fischer, D.D.S.

Taken from the Genova Nutreval

Specific Elements of the Chelative Sauna Defined

Exercise – At the capillary level, the cellular level, where much of this detoxing is to occur, an increase in blood pressure is needed to force new blood and oxygenation into these areas as well as to force out the toxins. It is estimated that at a minimum, 12 minutes of doubled heart rate is necessary to process the toxins of a NORMAL days metabolism. With the added burden of removing a lifetime of accumulated toxins, the minimum cardiovascular and doubling of the heart rate time is 20 minutes. This may of course need to be adjusted based upon the relative health of the participant.

Water – This process will liberate stored toxins, and water consumption is important to flush the toxins out of the system. Without proper water intake, the toxins will sit in the system where they can do damage, particularity to the glomerulus capillary network areas of the kidney which are the urinary filtration areas. Toxins liberated from fat storage areas and made water soluble must have the increased fluid intake to push them out of the body with the sweating. We use the Nikken water filtration system that not only filters the water, but mineralizes and ionizes it as well. The minimum requirement is 64 ounces for even the smallest adult.

Chelative agents and detoxification support elements

Chlorella- Chlorella is toxic binding to all known toxic metals and many environmental toxins. It is anti-viral. It is more effective at binding metals than any natural product known. It will not absorb from the gut into the bloodstream. This means that neuro-toxins that are dumped into the gut from the other chelators that do cross membranes such as cilantro and DMPS will be captured by the chlorella and safely exported via defecation. This binding is critical as without it, the toxins would likely be reabsorbed into the ENS (enteric nervous system). The ENS is a nerve plexus surrounding the intestines, and is highly prone to absorbing neurotoxins. The toxin, bound to chlorella cannot leave the gut, and this is the main reason for chlorella in the protocol.

It is given first so that it is in the gut when the other chelators start pulling toxins from the tissues. Chlorella is a single-celled algae that scientists postulate may be among the Earth’s oldest living organisms. In the 1960’s, Japanese scientists began to study chlorella for it’s health properties. We have now come to know chlorella well as a detoxifier, immune stimulator, and as an excellent source of cellular nutrition. The Chlorella produced by Mountain Rose Herbs has a cracked cell wall by a cryogenic jet-spray process that pulverizes the algae wall and allows for it to be digestible. It is grown organically in Japanese ponds free of exposure to industrial chemicals.

Garden of Life Q-Zymes with Beta Glucan and Cellulase- The Beta-Glucan and Cellulase in this product are specifically designed to digest the Chlorella cell wall, as well as further disrupt Biofilm of Bacterial and Fungal colonies in the gut.

DMPS- (2,3-dimercapto-1-propanesulfonic acid)

By prescription only. This is a chelative protein that will bind most metals, and is particularly effective at binding mercury. It will cross the gut lining as well as fatty tissues, and will therefore pull mercury from individual cells as well. It will not cross the blood brain barrier, and therefore will not directly remove mercury or other metals from the brain. This also means that it will not pull metals from the tissues and drive them into the brain, making it a safe first wave approach to clearing heavy metal toxins safely from body tissues. DMPS is specific for metals, and is not known to clear organic toxins.

NAC (N-Acetyl-Cysteine)

NAC can be produced in humans from the amino acid cysteine. NAC is a sulfur-containing amino acid derivative found naturally in foods and is a powerful antioxidant. These dual properties help repair oxidative damage in the body. Being a powerful anti-oxidant and cell detoxification co-factor, NAC works to eliminate your body of free radicals and heavy metals..

N-Acetyl-Cysteine is currently the dietary supplement of choice for building up cysteine or conserving the body’s store of Glutathione, Cysteine and other Sulfhydryl anti-oxidant resources. This is very crucial for the body’s life functions, as NAC helps the body neutralize toxins, heavy metals, such as mercury from dental amalgam fillings, cadmium and lead from paint and cigarette smoke. The Sulfhydryl balance has also been linked to enhance resistance to viral infections.

NAC is a chelator of heavy metals. In other words, NAC binds to toxic heavy metals such as mercury and lead, and removes them from the body. NAC will remove many toxic heavy metals from the body. Toxic metals can accumulate in the body over time from many sources such as drinking water and possibly even from tooth fillings made of silver-mercury amalgam. These heavy metals catalyze free-radical reactions. In other words, they initiate free-radical reactions without being used up during the reaction. So these heavy metals continue to cause free radical damage as long as they are present in the body. NAC has been shown to antidote acetaminophen (Tylenol) poisoning, mercury poisoning, and even arsenic poisoning. Mercury is especially important because of the increasing evidence linking mercury amalgam dental fillings with the onset of degenerative diseases such as Multiple Sclerosis. NAC chelates, i.e. “grabs” heavy metals and removes them from the body. NAC has been shown to be a protective agent in many diseases and conditions in which free radicals play a role. This includes cancer, AIDS, cirrhosis, as well as pollution damage from smoking or other chemicals. Rats given NAC were completely protected against cigarette smoke caused DNA cross-linking. Cancer research has shown that NAC dramatically reduces the ability of a tumor to invade surrounding tissue. In one study, NAC decreased the number of metastases by 80% when cancer cells were pretreated with NAC. NAC can be used for colon cancer prevention.

Oregano Oil- Oregano Oil is Highly anti-fungal for Candida and effective against the biofilm colonies of antibiotic resistant bacteria including Lyme disease. Mercury and other toxicity immunosuppresses a person and leaves them prone to infections. Oragano needs to be taken well prior to probiotics and for only the first week.

Catalyn –A Standard Process product containing full spectrum organic whole food derived Vitamin A, D and C as well as B1,B2, B6.

Niacin (B3), B6, Sublingual B12

B vitamins that are involved in neurochemistry synthesis and detoxification processes.

BioPure Freeze Dried Garlic –

“ Garlic protects white and red blood cells from the oxidative damage caused by metals traveling in the blood. Garlic also contains numerous Sulfur compounds which will oxidize Mercury, Cadmium and Lead making them water soluble. Garlic also contains bioactive Selenium, which has anti-viral properties and is the most important mineral for protection against Mercury Toxicity. Garlic also contains allicin which is nature’s most powerful anti-microbial.

The medicinal properties of fresh garlic have been known for centuries and it has been the mainstay anti-microbial of numerous civilizations through the ages. The problem that has arisen in presenting garlic as a supplement is the inherent instability of the initial active substance, allicin, which is created when a clove of garlic is crushed. Allicin is not found, as such, within the garlic clove. Instead, when the clove is crushed, allicin is formed instantaneously from the interaction on an enzyme called alliinase on a precursor of allicin called alliin.

“By selecting the highest quality garlic cloves, rich in alliin and alliinase, and then gently freeze-drying them, a concentrate powder is produced which only releases the prime active allicin component when ingested and re-hydrated, i.e. all the allicin is released within the gastrointestinal tract. This is how BioPure is able to make the highest possible potency garlic available as a concentrate with all of the active components intact.” Text taken from BioPure Website

CaEDTA-

Ethylene-Diamine-Tetra-Acetic Acid. CaEDTA is used as a chelating agent in the treatment of lead poisoning, and CaEDTA also binds cadmium. It also Chelates, Zinc, and it’s use requires re-supplementation with Zinc several hours after administration.

BioPure Cilantro Tinticure (STAGE 2)-

“This kitchen herb is capable of mobilizing lead, aluminum, nickel, mercury, and cadmium is the central nervous system and in the bones. It is probably the only effective agent in mobilizing mercury stored in the intracellular space (attached to mitochondria, tubulin, liposomes etc.) and in the nucleus of the cell (reversing DNA damage of mercury).”-Dietrich Klinghardt Eliminating Neurotoxins Townsend Letter Oct 2009

Cilantro does cross the blood brain barrier, and is used in stage 2 for that reason. Since Cilantro can mobilize toxins in cells, and mobilize more toxins than it can carry out of the body, it needs to be combined with Chlorella to prevent re-toxification. It is important to give the Chlorella prior to the Cilantro so as to line the gut with large molecule Chlorella chelators which will bind the toxins liberated by the Cilantro. Cilantro has demonstrated a more rapid removal of aluminum and lead from the skeleton than any other known detox agent.

Vitamin C: Primary Water-Soluble Antioxidant

Vitamin C is the most important water-soluble antioxidant nutrient and is involved in a wide variety of biochemical reactions throughout the body. Because of its molecular structure, vitamin C is able to donate hydrogen atoms from two hydroxyl positions to neutralize free radicals. The body uses vitamin C during detoxification and anti-inflammatory processes, as well as immune system functions, including white blood cell production, histamine release and degradation, the reduction of glutathione, and the metabolism and protection of several other nutrients. In combination with other nutrients, vitamin C also supports the production of certain neurotransmitters.

Salts/Potassium

As needed to replace minerals lost via sweating. During sweating, Sodium and Potassium are lost and need to be replaced.

Sam-E S-Adenosyl methionine is a common co-substrate involved in methyl group transfers. The methyl group (CH3) attached to the methionine sulfur atom in SAM is chemically reactive. This allows donation of this group to an acceptor substrate in transmethylation reactions. Transmethylation is an important step in converting a reactive toxin into a harmless water soluble substance that the body can then easily eliminate. Blister packs keep the product safe from degradation, which is a particular issue with Sam-E

Three-dimensional picture of Methyl Transfer

Coconut Oil-

Coconut oil is good for the immune system. It strengthens the immune system as it contains antimicrobial lipids, lauric acid, capric acid and caprylic acid which have antifungal, antibacterial and antiviral properties. The human body converts lauric acid into monolaurin which is claimed to help in dealing with viruses and bacteria causing diseases such as herpes, influenza, cytomegalovirus, and even HIV. It helps in fighting harmful bacteria such as listeria monocytogenes and heliobacter pylori, and harmful protozoa such as giardia lamblia.

Total Amino Solution This product contains all the precursors necessary to synthesize neurotransmitters. It is promoted by Julia Ross, author of the Mood Cure Diet. Neurochemistry is dramatically impacted by the presence of toxins, and this formula is designed to help repair that damage.

Evening Primrose Oil-

The main active ingredient in EPO is an omega-6 fatty acid known as gamma-linolenic acid (GLA). In neurotoxic people, we typically see an inappropriate ratio of fatty acids; that is, too much Omega 3 and not enough Omega 6. This is the exact opposite of what most doctors tell their patients. When this ratio is not present, the cell and the body become toxic. This optimum balance of FA’s makes up the cellular membrane that lets nutrition in and waste out.

Lecithin-

Enzymes such as bile, which are produced in the liver, help with digestion and the breakdown of various chemicals inside the body. Without lecithin these enzymes would cease to be effective. Lecithin is a powerful fat-emulsifying compound. It solubilizes fats and cholesterol in the bloodstream and solubilizes dietary fats in the intestinal mucosa. It maintains the structural integrity of cell membranes. Since most toxins are fat-soluble, Lecithin is important in exchanging toxin laden fats with good fats.

Re-mineralization-

As chelators such as EDTA and DMPS can remove good minerals, the good minerals need to be replaced, and the re-mineralization needs to occur after the active period for the chelators. Adding minerals at the same time as the chelating agents would dilute the effectiveness of the chelators, hence, they are given 2 hours after the primary chelators.
Seleno- Methionine-

Selenium bound to Methionine. During digrestion, the Methionine will split off of the Selenium. This not only makes the Selenium Bio-available, but the Methionine itself contributes to the Methylation aspect of detoxification. Good minerals will compete with toxic ones, and the good minerals can replace toxic ones at the sites where there are bound within the neurology. Selenium is one of the good minerals, and the most important mineral to protect against Mercury toxicity. There is some question still about the bio-availability of the Selenium in Selenomethione, and hence the added reasoning for the freeze-dried garlic, a highly bio-available form of Selenium.

Garden of Life Living Multi- A broad-based whole food vitamin and mineral supplement containing a potent blend of antioxidant–rich ingredients derived from naturally grown and organic fruits, vegetables, tonic mushrooms, sea vegetables, and botanicals, plus trace minerals that supply nutrients important for general health and well-being.

Cal-Mag – Cal Mag being used here to insure proper remineralization lost from the Chelative Process and the sweating.

Zinc Liver Chelate – Zinc is lost when a person is metal toxic, and when the body is under any form of stress, especially infections. Infections are common with toxicity. Zinc is also chelated out by this process and need to be replaced.

BioPure Matrix Minerals Fulvic Acid has been called one of the most important natural miracles related to life itself.  It is an acid created in extremely small amounts by millions of beneficial microbes working on decaying plant matter.

Because of fulvic acid’s low molecular weight (small molecules) it has the ability to readily dissolve and bond minerals and nutritional elements into its molecular structure.  Nutrients that have been chelated by fulvic acid are in an ideal natural form to interact with and be absorbed by living cells. Fulvic Acid is so powerful that one single fulvic acid molecule is capable of carrying  60 or more minerals and trace elements into the cells.

Super-Conductive Ionic Minerals

Re-mineralize and Recharge with Ambaya Gold’s Super-Conductive Ionic Minerals in a Fulvic Base

Ambaya Gold’s liquid Ionic Mineral formula provides essential nutrients to re-mineralize and recharge your body and mind after the sweating a chelative process which tends to draw out minerals. Minerals hold the electrical ground and conductivity of the body and displace toxic metals- this easy to use formula is a great way to supply essential minerals and other key ingredients required to stay strong, vital, and connected.